in the title of the published article in online edition “Days.Ru”, citing CellDiscovery international journal that publishes cutting edge research in all areas of molecular and cell biology. The journal belongs to the group of the academic publishing company Springer Nature, published in cooperation with the Chinese Academy of Sciences.
this study evaluated six available antiviral drugs against the new coronavirus SARS-CoV-2: balaclavas, laninamivir, oseltamivir, peramivir and zanamivir and umifenovir, known in Russia as “Arbidol”.
Scientists Wuhan Institute of Virology of the Chinese Academy of Sciences studied the antiviral activity and cytotoxicity of drugs in the cells of African green monkeys and these two indicators were evaluated the antiviral activity of the so – called “selectivity index” SI.
According to the network edition, among all the studied drugs umifenovir (“Arbidol”) most effectively inhibited the virus SARS-CoV-2, SI made up of 7.73. Balaclavas partially inhibited the infection of SARS-CoV-2, not more than 29%, when the concentration is high. “At the same time laninamivir, oseltamivir, peramivir and zanamivir, in contrast, showed no activity against SARS-CoV-2 even at the highest concentrations” – the newspaper writes.
for More detailed microscopic study showed that umifenovir blocks the penetration of SARS-CoV-2 in cells, leading to a significant reduction in the efficiency of binding (67%) compared to the control group, respectively, the proportion of unbound virions, that is, the number is not attached viruses to the cells, significantly increased to 156%.
Wang, X., Cao, R., Zhang, H. etal. The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov 6, 28 (2020). https://doi.org/10.1038/s41421-020-0169-8
https://www.nature.com/articles/s41421-020-0169-8
