Hypercarotenemia – uncontrolled activation of immune cells by anti-inflammatory molecules cytokines. The resulting immune cells start a cascade of cytokines release all new, and those, in turn, stimulate new immune cells. As a result, they destroy not only tissue inflammation but also the surrounding tissue. The reaction can spread throughout the body, leading to systemic inflammation, organ failure and death. In the case of coronavirus cytokinemic storm can cause acute respiratory failure that ends in death.
the Drug with the active substance tocilizumab, usually used to treat rheumatoid arthritis, was tested in the experiment, which was attended by 129 people. 65 of them took tocilizumab, other 64 received only conventional treatment.
Among patients taking tocilizumab, there were fewer cases of necessity of application of the ventilator, as well as significantly fewer of these patients died within two weeks after the onset of the disease.
This experiment, as stated in the publication on the website should be confirmed by additional studies. The publication on the website APHP provides too little data to judge the effectiveness of the drug and the test group too small for conclusive findings.
Besides the substance tocilizumab (an immunosuppressant, a suppressive cytokines IL-6) is not excluded, that suppresses antitumor and anti-infective protection of the body, this is stated in the instructions for medical use of the drug.
At the present time doctors around the world are in the fight against coronavirus variety of products that are supposed to help with the Covid-19. Since all the work is in emergency mode, then there is a lot of hasty publications that do not have sufficient evidence and were not properly discussed in the scientific community. However, this information may be useful in the further development of drugs against the coronavirus.
