according to Skvortsov, in the course of testing the drug “completely blocked the development of the cytopathic action of the virus in cell culture at a concentration of 2 mg per 1 l, which is achieved in plasma after administration in therapeutic doses, allowed for the man.” And already after a single dose of the drug at a dose of 750 mg/day. (3 tablets of 250 mg) “the maximum concentration in the blood plasma during the first days reaches of 1.51 µg/l”.
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Next, as said the head of FBMA, while continuing reception of “Mefloquine” 500 mg (2 tablets of 250 mg) concentration in blood plasma increases and is “already on the second or third day, reaches 2,7-3,8 µg/l, providing the elimination of the virus.
the Further course drug in a dose of 250 mg (1 tablet per day) allows to maintain the required concentration throughout the entire course of therapy (7 days) and “within a few days after. I expected him to doctors and biologists engaged in the development of medicines against Chinese coronavirus.
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the Agency said that the study of clinical effects of the drug is in ongoing comparative study in three centers of the FMBA of Russia – state research center center named after them. A. I. Burnazyan of FMBA of Russia, Federal research and clinical centre of FMBA of Russia, the FCC VMT FMBA of Russia”. As head of troops to chemical and biological defense Igor Kirillov said that the studies involved specialists of the 48th Central research Institute of the troops of radiation, chemical and biological protection of the armed forces who have tested the drug in a specially chosen laboratory model animal “in susceptibility to coronavirus closest to the man.”