Unexpected: common female disease predicted for weight and height in childhood

Endometriosis is a common gynecological disease in which endometrial cells (the inner layer of the wall of the uterus) grow outside of this layer.

This disease is accompanied by excruciating pain in the pelvic region and can lead to infertility. It also increases the risk of developing other serious diseases, including cardiac and cancer.

Despite the numerous data and the existing treatment, the causes of endometriosis, and the risk factors, till now precisely is not established.

In the new work, researchers from Denmark found that the risk of disease in women may depend on a seemingly unexpected factors.

the Authors examined the medical data of over 170 thousand patients born in the years 1930-1996. Each of them has aged 7-13 years were measured height and weight. These data have become fundamental in the new work.

In the course of the observations were registered with 2149 cases of endometriosis and 1,410 cases of adenomyosis (internal genital endometriosis).

analysis of the data showed that women who had in childhood higher body mass index (BMI) had a lower risk of endometriosis than those who in childhood were distinguished by thinness and had a high growth (respectively, lower BMI).

for Example, if at the age of seven years, one girl weighed less than the other approximately 2.3 kilograms, in the future, the likelihood of developing endometriosis it increased by 8% compared to more a fad age, researchers say.

meanwhile, the difference in height of about 5.2 cm was associated with an increased risk of 9% (the higher girls).

it is Noted that such correlation were detected in relation to adenomyosis. Also there was no interaction between the risk of endometriosis or adenomyosis and weight at birth.

Experts believe that the correlation is likely to be associated not with socio-economic factors, and biological mechanisms as tendance survived for 66 years.

“Our results show that indicators of risk [of endometriosis] can be obtained at an early age. This can help to speed up diagnosis to early treatment and to slow the growth of endometrial tissue,” said lead author Julie Aarestrup (Julie Aarestrup) from the Danish center for clinical research and prevention.

In the future, scientists intend to find out what explains the data.

In their view, a key role could be played by elevated levels of estrogen. In puberty this hormone is crucial for the growth of “tall” and at the same time, it promotes the growth of endometrial cells.

as for the index of body mass, then this relationship more difficult to explain. Greater body weight is usually associated with more early onset of menstruation and, as shown by new work, with a reduction in the likelihood of developing endometriosis. However, there is strong evidence that early period, by contrast, is a risk factor for developing this disease. Therefore, the timing of puberty are unlikely to explain the new findings, experts conclude.

Article on the results of their study are published in the publication Annals of Human Biology.

earlier, “Conduct.Science” (nauka.vesti.ru) told me about a new method of treatment that does not lead to infertility.

Text: To.Science