Well-known antibiotic has coped with persistent form of Lyme disease

Scientists have discovered a drug that can deal with the resistant strains of the causative agent of Lyme disease. The drug is already approved for use against other infections.

Achievement is described in a scientific paper published in the journal Scientific Reports.

Lyme Disease, or borreliosis, is a serious disease carried by ticks. It is caused by bacteria of the genus Borrelia, B. burgdorferi is mainly. The disease affects the nervous system (including brain), heart, joints, skin, and other organs. Each year they catch more than 300 thousand people. Vaccines against this infection does not exist.

In the early stages of the disease can be defeated with antibiotics (specifically doxycycline). But 10-20% of patients are not helping the traditional treatment. They suffer from pain, cognitive impairment and other severe symptoms for a very long time, sometimes a lifetime.

What is called the long course of the disease, is not known. But more and more data appears that the case is resistant to common medications strains of the causative agent.

About ten years ago, a group led by Jayakumar Rajabasa (Jayakumar Rajadas) from Stanford University engaged in the search for new drugs for the treatment of Lyme disease. Scientists tested nearly 8,000 chemical compounds. The 50 most promising of these have been tested “in vitro” on cell cultures. In the end, the authors selected 20 favorites. It is important that all these substances were already approved by regulatory authorities for treatment of other diseases, so doctors do not have to re-prove their safety.

the new article the authors report on trials of azlocillin on infected mice. It turned out that this is a common antibiotic to cope with B. burgdorferi is better and has fewer side effects than the closest analogues.

“This connection is simply amazing — recognized Rajadas. It eliminates the infection without causing a large number of side effects. We hope to use it for the oral treatment of Lyme disease”.

in addition, aslacIllin was tested “in vitro” on strains of bacteria that are resistant to doxycycline. Here he also showed his effectiveness. With resistant strains was good and another well-known antibiotic — Cefotaxime. Now the authors are planning to confirm these results in experiments on animals.

By the way, earlier “Conduct.Science” (nauka.vesti.ru) wrote that the causative agent of Lyme disease were older than the human race.

Text: To.Science