proton pump Inhibitors (PPIS) class of drugs for the treatment of acid-related diseases of the gastrointestinal tract (dyspepsia, chronic gastritis and pancreatitis, gastric ulcer and duodenal ulcer, etc.).
These medications are often used to treat adults and children. They are sold by prescription and without prescription.
According to the researchers, historically, IPP was considered “very safe”, although some studies suggested that the drugs may be associated with a wide range of complications.
In particular, a few years ago the Management on sanitary inspection behind quality of foodstuff and medicines of the United States presented evidence that in adults, prolonged use of PPIS and use of such drugs in large doses, increases the risk of fractures of hip, wrist and spine.
In the new work, researchers found that the same “side effect” is observed in children and adolescents.
the Team analyzed the information collected in 51 pediatric hospital in the U.S. over a four-year period (2011 to 2015). In total, there were 32 analyzed thousands of cases where patients received proton pump inhibitors, and when treatment did not include the use of such drugs.
Specifies that from the sample were excluded patients who had diseases or took drugs, which may increase the likelihood of fracture.
analysis of the data showed that under equal risk factors the likelihood of fractures in children taking PPIS is 20% higher than children not receiving such medications.
it is Also noted that in both groups the most common were fractures of the upper extremities (bones of the hand, wrist). As for fractures of the lower extremities (bones of the legs and feet), ribs or spine, they often occurred in children taking proton pump inhibitors.
in addition, in both groups the fractures most often happen in the children from one year to three years and nine to 13 years.
the data indicate a “class effect” of IPP. In other words, the fracture risk increases with use of all drugs of this class, not any particular medication or combination, the researchers note.
In their view, the new data emphasizes the need for careful monitoring of children who receive proton pump inhibitors. In the appointment of treatment physicians should consider the risks associated with taking such drugs and report them to parents of young patients.
Scientific article on the results of this work are presented in the Journal of Pediatric Gastroenterology and Nutrition.
by the Way, earlier “Conduct.Science” (nauka.vesti.ru) talked about whether calcium and vitamin D may protect people from fractures.