Scientists at the University of Bristol (UK) conducted an unusual experiment. They examined blood tests in children, taken in the 90-ies and compared them with the current state of health thirty years later.
In the study, as reported in the medical journal Diabetes Care, included children of different ages on the four key stages of early life-childhood (age 8 years), adolescence (16 years), young age (18 years) and maturity (25 years), only about 4,000 people. None of them thirty years ago did not have any chronic diseases, including type II diabetes.
diseases Such as diabetes, do not appear in one night, scientists say. But at what stage appear in the body of the first markers of this disease? The search for the answer to this question was the main goal of researchers. Every blood test has been studied for possible changes in the structure of genes that predated, after decades, the emergence of signs of diabetes.
the study confirmed that a violation lipid metabolism of high density lipoprotein is one of the earliest features of type II diabetes, along with higher levels of branched chain amino acids and inflammatory processes. Some of the features already evident at the age of 8 years, in the decades before the clinical onset of the disease.
the Technique, developed by scientists at Bristol University, based on indicators of metabolic rate of metabolism. It is possible to predict the development of diabetes mellitus almost fifty years before the appearance of the first symptoms.
“Diabetes type II diabetes develops over many years before diagnosis. We aimed to identify early metabolic features characterizing the predisposition to adult disease, studying the genetic predisposition to diabetes mellitus during the entire period of early life. The data indicate that we are approaching the discovery of the biological causes of disease, which is usually attributed to costs of civilization, and the sooner we can identify markers of the disease, the more effective and more efficient will be the treatment,” the researchers write. This knowledge will help as early as possible to help patients.
Diabetes type II diabetes is usually diagnosed when the level of blood glucose is 7 mmol/l as fasting or 11.1 mmol/l in the state after a call or when the level of glycated hemoglobin is not more than 6.5%.
